212 research outputs found
Sleep disorders and gastrointestinal symptoms: chicken, egg or vicious cycle?
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75369/1/j.1365-2982.2008.01254.x.pd
Dietary guidelines for irritable bowel syndrome are important for gastroenterologists, dietitians and people with irritable bowel syndrome
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134108/1/jhn12413_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134108/2/jhn12413.pd
American College of Gastroenterology Guideline on the Management of Helicobacter pylori Infection
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73792/1/j.1572-0241.2007.01393.x.pd
Pharmacologic and Complementary and Alternative Medicine Therapies for Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by episodic abdominal pain or discomfort in association with altered bowel habits (diarrhea and/or constipation). Other gastrointestinal symptoms, such as bloating and flatulence, are also common. A variety of factors are believed to play a role in the development of IBS symptoms, including altered bowel motility, visceral hypersensitivity, psychosocial stressors, altered brain-gut interactions, immune activation/low grade inflammation, alterations in the gut microbiome, and genetic factors. In the absence of biomarkers that can distinguish between IBS subgroups on the basis of pathophysiology, treatment of this condition is predicated upon a patient's most bothersome symptoms. In clinical trials, effective therapies have only offered a therapeutic gain over placebos of 7-15%. Evidence based therapies for the global symptoms of constipation predominant IBS (IBS-C) include lubiprostone and tegaserod; evidence based therapies for the global symptoms of diarrhea predominant IBS (IBS-D) include the probiotic Bifidobacter infantis, the nonabsorbable antibiotic rifaximin, and alosetron. Additionally, there is persuasive evidence to suggest that selected antispasmodics and antidepressants are of benefit for the treatment of abdominal pain in IBS patients. Finally, several emerging therapies with novel mechanisms of action are in development. Complementary and alternative medicine therapies including probiotics, herbal therapies and acupuncture are gaining popularity among IBS sufferers, although concerns regarding manufacturing standards and the paucity of high quality efficacy and safety data remain
The utility of diagnostic tests in irritable bowel syndrome patients: a systematic review
The aim of this study was to determine the pretest probability of organic GI disease and the accuracy of diagnostic tests for organic GI disease in patients who meet symptom-based criteria for irritable bowel syndrome (IBS). METHODS : After a comprehensive literature search for studies examining the accuracy of diagnostic tests for organic GI disease among patients who meet symptom-based criteria for IBS, two independent observers qualitatively assessed the methodology of selected studies and extracted data. Data on the pretest probability of organic GI disease in this population and the accuracy of currently recommended diagnostic tests were converted to descriptive tables. RESULTS : Among patients meeting symptom-based criteria for IBS, the pretest probability of inflammatory bowel disease, colorectal cancer, or infectious diarrhea is less than 1%. Currently recommended diagnostic tests rarely identify organic GI disease in patients fulfilling symptom-based criteria for IBS. However, the pretest probability of celiac disease in patients meeting symptom-based criteria for IBS was 10 times higher than the prevalence of celiac disease in the general population. CONCLUSION : There is insufficient evidence to recommend the routine performance of a standardized battery of diagnostic tests in patients who meet symptom-based criteria for IBS. Based upon the increased pretest probability of celiac disease, routine performance of serological tests for celiac disease may be useful in this patient population, though additional study is needed in this area.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72511/1/j.1572-0241.2002.07027.x.pd
Levofloxacin-Based Triple Therapy versus Bismuth-Based Quadruple Therapy for Persistent Helicobacter pylori Infection: A Meta-Analysis
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73094/1/j.1572-0241.2006.00637.x.pd
Appropriate timing of the 14 C-urea breath test to establish eradication of Helicobacter pylori infection
The aim of this study was to determine the performance characteristics of the 14 C-urea breath test (UBT) performed 2 wk after the completion of therapy for Helicobacter pylori using a 4 to 6 wk study as the gold standard. METHODS : Patients with active Helicobacter pylori infection at four medical centers received proton pump inhibitor-based triple or quadruple therapy for 10â14 days. Patients underwent the 14 C-UBT 2 and 4â6 wk after the completion of therapy. A positive test was defined as 14 CO 2 excretion of >200 dpm, a negative test as 50 but <200 dpm. Performance characteristics of the 2-wk UBT were calculated using the 4 to 6-wk result as a gold standard. RESULTS : Eighty-five patients were enrolled and 82 patients (mean ± SD age, 62 ± 15 yr; 15 women) completed the protocol. Four patients had equivocal UBT results and were excluded from the analysis. Of the 78 patients, 68 (87%) had a negative 4 to 6-wk UBT. The 2-week UBT yielded a sensitivity of 90% (95% confidence interval 72â100%), specificity of 99% (97â100%), and accuracy of 97% (93â100%). In patients with a persistently positive UBT, 14 CO 2 excretion at 2 wk was significantly lower than at 4â6 wk after therapy ( p = 0.03 ). CONCLUSIONS : A UBT performed 2 wk after therapy yielded results comparable to 4 to 6 wk testing. Further studies to evaluate the optimal time of confirmatory testing in the age of more effective proton pump inhibitor-based triple therapies are warranted.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73434/1/j.1572-0241.2000.02005.x.pd
Tegaserod for Female Patients Suffering From IBS With Mixed Bowel Habits or Constipation: A Randomized Controlled Trial
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73726/1/j.1572-0241.2008.01808.x.pd
Nuances of the psychogastroenterology patient: A predictive model for gastrointestinal quality of life improvement
BackgroundGastrointestinal conditions are multifactorial in nature, and certain patients can benefit greatly from brainâgut psychotherapies delivered by mental health professionals who specialize in psychogastroenterology. This study aimed to identify features associated with improvements in GIâspecific quality of life scores following behavioral health interventions (BHI). The second aim was to create a psychogastroenterology referral care pathway incorporating identified characteristics for greatest benefit from GIâspecific behavioral therapy.MethodsWe performed a prospective observational study of 101 (63 women; median age, 45Â years) gastroenterology patients referred for psychogastroenterology consultation at a single center. Patients attended an average of seven sessions with a single GI psychologist where evidenceâbased brainâgut psychotherapies were employed. GIâspecific quality of life (IBSâQOL) and psychological distress (BSIâ18) were assessed before and after BHI. Patients completed selfâreported questionnaires. We performed a multivariable analysis to determine predictors associated with IBSâQOL score improvement.Key ResultsA total of 53 (52.5%) patients experienced improvement in IBSâQOL score. Patients with improved IBSâQOL scores had significantly higher baseline BSI general domain Tâscores (61.9 vs. 56.9, PÂ =Â 0.002). Female gender (odds ratio [OR], 3.2), pretreatment BSI somatization Tâscore â„63 (OR, 3.7), and a diagnosis of depression (OR, 4.2) were associated with greater odds of IBSâQOL score improvement following BHI.Conclusions and InferencesWe identified factors associated with response to GIâspecific BHI to aid in optimizing the utilization of psychogastroenterology services and provide referring providers with information to inform treatment recommendations. Female patients with disorders of gutâbrain interaction (DGBIs), high somatization, and depression should be considered a priority for brainâgut psychotherapies.Gastrointestinal conditions are multifactorial in nature, and certain patients can benefit greatly from brainâgut psychotherapies delivered by mental health professionals who specialize in psychogastroenterology. Females with disorders of gutâbrain interaction, high somatization, and depression should be considered priority for brainâgut psychotherapies. Behavioral health outcomes were not limited to disease; patients with IBD should be routinely considered for referral. Optimizing utilization of GIâspecific behavioral health specialists for the best outcomes can maximize quality of life and disease experience, but also improve valueâbased care.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151345/1/nmo13663.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151345/2/nmo13663_am.pd
Safety and patient outcomes with lubiprostone for up to 52Â weeks in patients with irritable bowel syndrome with constipation
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90244/1/apt4983.pd
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